Efficient tuberculosis treatment in mice using chemotherapy and immunotherapy with the combined DNA vaccine encoding Ag85B, MPT-64 and MPT-83

Protection of mice with a divalent tuberculosis DNA vaccine encoding antigens Ag85B and MPT64.

DNA vaccine may be a promising tool for controlling tuberculosis development. However, vaccines encoding single antigens of mycobacterium did not produce protective effect as BCG did. In the present study, we evaluated the immunogenicity and protective efficacy of a divalent DNA vaccine encoding two immunodominant antigens Ag85B and MPT64 of Mycobacterium tuberculosis. We found that both humora...

Rapid confirmation of drug susceptibility in Mycobacterium tuberculosis using MPT 64 Ag based test Ernest

Rapid confirmation of drug susceptibility in Mycobacterium tuberculosis using MPT 64 Ag based test Ernest Afu Ochang, Oyinlola O. Oduyebo, Ifeanyi A. Onwuezobe, Sunday M. Obeten, Godwin I. Ogban, Ubleni E. Emanghe Department of Medical Microbiology and Parasitology, University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria Department of Medical Microbiology and Parasitology, ...

Multi-Parametric Toolbox (MPT)

Crossover confusion: MPT still best.

weaken the binding of the protein to its targeted DNA but retain a similar protein structure. It is this second class that both gives rise to the adverse prognosis of DLBCL and often demonstrates allele-specific “gain-of-function mutations”5,6 that confers new properties on a mutant p53 protein. These mutant proteins apparently bind to other transcription factors (like p73) and alter their func...

the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group

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